ea0026p517 | Bone/calcium/Vitamin D | ECE2011
Oei H L D W
, Estrada K
, Castano-Betancourt M C
, van der Klift M
, Kerkhof J M
, Hofman A
, Pols H A P
, Stolk L
, van Meurs J B
, Zillikens M C
, Uitterlinden A G
, Rivadeneira F
Risk for vertebral fractures (VFx), the most common osteoporotic fractures, is a heritable complex trait. No genome-wide association studies (GWAS) searching for genetic susceptibility factors for VFx have been reported. We performed a GWAS for VFx in a population-based study of Dutch elderly. Thoracolumbar spine radiographs were scored for osteoporotic VFx using the McCloskey/Kanis method. Genetic data was available in 329 VFx cases and 2666 controls. We tested 2 543 887 impu...